Mismatched single stranded antisense oligonucleotides can induce efficient dystrophin splice switching

BACKGROUND: Antisense oligomer induced exon skipping aims to reduce the severity of Duchenne muscular dystrophy by redirecting splicing during pre-RNA processing such that the causative mutation is by-passed and a shorter but partially functional Becker muscular dystrophy-like dystrophin isoform is...

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Bibliografski detalji
Glavni autori: Fragall, Clayton T, Adams, Abbie M, Johnsen, Russell D, Kole, Ryszard, Fletcher, Sue, Wilton, Steve D
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213239/
https://ncbi.nlm.nih.gov/pubmed/22013876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-12-141
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