Investigation of age-related changes in LMNA splicing and expression of progerin in human skeletal muscles

Age-related changes in splice-forms of LMNA, which encodes the nuclear lamina proteins lamin A/C, have not been investigated in skeletal muscle. In the rare premature ageing disease, Hutchinson-Gilford progeria syndrome (HGPS), de novo point mutations in LMNA activate a cryptic splice site in exon 1...

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Bibliografiske detaljer
Main Authors: Luo, Yue-Bei, Mitrpant, Chalermchai, Johnsen, Russell D, Fabian, Victoria A, Fletcher, Sue, Mastaglia, Frank L, Wilton, Steve D
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843258/
https://ncbi.nlm.nih.gov/pubmed/24294364
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