Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy

BACKGROUND: Mutations in the LMNA gene are a common cause (6–8%) of dilated cardiomyopathy (DCM) leading to heart failure, a growing health care problem worldwide. The premature aging disease Hutchinson-Gilford syndrome (HGPS) is also caused by defined mutations in the LMNA gene resulting in activat...

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Udgivet i:PLoS One
Main Authors: Messner, Moritz, Ghadge, Santhosh Kumar, Goetsch, Valentina, Wimmer, Andreas, Dörler, Jakob, Pölzl, Gerhard, Zaruba, Marc-Michael
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922532/
https://ncbi.nlm.nih.gov/pubmed/29702688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196739
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