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A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF

Platelet-derived growth factor BB and its receptor (PDGFRβ) play a pivotal role in the development of renal glomerular mesangial cells. Their roles in increased mesangial cell proliferation during mesangioproliferative glomerulonephritis have long been noted, but the operating logic of signaling mec...

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Main Authors: Bera, Amit, Das, Falguni, Ghosh-Choudhury, Nandini, Li, Xiaonan, Pal, Sanjay, Gorin, Yves, Kasinath, Balakuntalam S., Abboud, Hanna E., Ghosh Choudhury, Goutam
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2014
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042091/
https://ncbi.nlm.nih.gov/pubmed/24740537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00387.2013
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