Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B

Mesangioproliferative glomerulonephritis is associated with overactive PDGF receptor signal transduction. We show that the phytoalexin resveratrol dose dependently inhibits PDGF-induced DNA synthesis in mesangial cells with an IC(50) of 10 μM without inducing apoptosis. Remarkably, the increased SIR...

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Autori principali: Venkatesan, Balachandar, Ghosh-Choudhury, Nandini, Das, Falguni, Mahimainathan, Lenin, Kamat, Amrita, Kasinath, Balakuntalam S., Abboud, Hanna E., Choudhury, Goutam Ghosh
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Federation of American Societies for Experimental Biology 2008
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2537424/
https://ncbi.nlm.nih.gov/pubmed/18567737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-109488
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