HIGH GLUCOSE UPREGULATION OF EARLY-ONSET PARKINSON’S DISEASE PROTEIN DJ-1 INTEGRATES THE PRAS40/TORC1 AXIS TO MESANGIAL CELL HYPERTROPHY

The Akt kinase signaling pathway is frequently deregulated in many human diseases including cancer, autoimmune disease and diabetes. In nephropathy, associated with diabetes, increased Akt signal transduction results in glomerular especially mesangial cell hypertrophy. The mechanism of Akt activatio...

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Detalhes bibliográficos
Main Authors: Das, Falguni, Dey, Nirmalya, Venkatesan, Balachandar, Kasinath, Balakuntalam S., Ghosh-Choudhury, Nandini, Choudhury, Goutam Ghosh
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104472/
https://ncbi.nlm.nih.gov/pubmed/21426932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2011.03.012
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