High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression

High glucose milieu inhibits PTEN expression to activate Akt kinase and induces glomerular mesangial cell hypertrophy and matrix protein expression in diabetic nephropathy. Specific mechanism by which high glucose inhibits PTEN expression is not clear. We found that high glucose increased the expres...

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Publicado no:Cell Signal
Main Authors: Dey, Nirmalya, Bera, Amit, Das, Falguni, Ghosh-Choudhury, Nandini, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437875/
https://ncbi.nlm.nih.gov/pubmed/25797045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2015.03.007
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