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High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression

High glucose milieu inhibits PTEN expression to activate Akt kinase and induces glomerular mesangial cell hypertrophy and matrix protein expression in diabetic nephropathy. Specific mechanism by which high glucose inhibits PTEN expression is not clear. We found that high glucose increased the expres...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cell Signal
Hauptverfasser: Dey, Nirmalya, Bera, Amit, Das, Falguni, Ghosh-Choudhury, Nandini, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437875/
https://ncbi.nlm.nih.gov/pubmed/25797045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2015.03.007
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