microRNA-181a Downregulates Deptor for TGFβ-induced Glomerular Mesangial Cell Hypertrophy and Matrix Protein Expression

TGFβ contributes to mesangial cell hypertrophy and matrix protein increase in various kidney diseases including diabetic nephropathy. Deptor is an mTOR-interacting protein and suppresses mTORC1 and mTORC2 activities. We have recently shown that TGFβ-induced inhibition of deptor increases the mTOR ac...

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Bibliographische Detailangaben
Veröffentlicht in:Exp Cell Res
Hauptverfasser: Maity, Soumya, Bera, Amit, Ghosh-Choudhury, Nandini, Das, Falguni, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825286/
https://ncbi.nlm.nih.gov/pubmed/29397070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2018.01.021
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