High Glucose Forces a Positive Feedback Loop Connecting Akt Kinase and FoxO1 Transcription Factor to Activate mTORC1 Kinase for Mesangial Cell Hypertrophy and Matrix Protein Expression

High glucose-induced Akt acts as a signaling hub for mesangial cell hypertrophy and matrix expansion, which are recognized as cardinal signatures for the development of diabetic nephropathy. How mesangial cells sustain the activated state of Akt is not clearly understood. Here we show Akt-dependent...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Das, Falguni, Ghosh-Choudhury, Nandini, Dey, Nirmalya, Bera, Amit, Mariappan, Meenalakshmi M., Kasinath, Balakuntalam S., Ghosh Choudhury, Goutam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239622/
https://ncbi.nlm.nih.gov/pubmed/25288788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.605196
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