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High Glucose Forces a Positive Feedback Loop Connecting Akt Kinase and FoxO1 Transcription Factor to Activate mTORC1 Kinase for Mesangial Cell Hypertrophy and Matrix Protein Expression

High glucose-induced Akt acts as a signaling hub for mesangial cell hypertrophy and matrix expansion, which are recognized as cardinal signatures for the development of diabetic nephropathy. How mesangial cells sustain the activated state of Akt is not clearly understood. Here we show Akt-dependent...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Das, Falguni, Ghosh-Choudhury, Nandini, Dey, Nirmalya, Bera, Amit, Mariappan, Meenalakshmi M., Kasinath, Balakuntalam S., Ghosh Choudhury, Goutam
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239622/
https://ncbi.nlm.nih.gov/pubmed/25288788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.605196
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