A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF

Platelet-derived growth factor BB and its receptor (PDGFRβ) play a pivotal role in the development of renal glomerular mesangial cells. Their roles in increased mesangial cell proliferation during mesangioproliferative glomerulonephritis have long been noted, but the operating logic of signaling mec...

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Detalhes bibliográficos
Main Authors: Bera, Amit, Das, Falguni, Ghosh-Choudhury, Nandini, Li, Xiaonan, Pal, Sanjay, Gorin, Yves, Kasinath, Balakuntalam S., Abboud, Hanna E., Ghosh Choudhury, Goutam
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042091/
https://ncbi.nlm.nih.gov/pubmed/24740537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00387.2013
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