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A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF
Platelet-derived growth factor BB and its receptor (PDGFRβ) play a pivotal role in the development of renal glomerular mesangial cells. Their roles in increased mesangial cell proliferation during mesangioproliferative glomerulonephritis have long been noted, but the operating logic of signaling mec...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Physiological Society
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4042091/ https://ncbi.nlm.nih.gov/pubmed/24740537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00387.2013 |
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