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A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF

Platelet-derived growth factor BB and its receptor (PDGFRβ) play a pivotal role in the development of renal glomerular mesangial cells. Their roles in increased mesangial cell proliferation during mesangioproliferative glomerulonephritis have long been noted, but the operating logic of signaling mec...

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Detaylı Bibliyografya
Asıl Yazarlar: Bera, Amit, Das, Falguni, Ghosh-Choudhury, Nandini, Li, Xiaonan, Pal, Sanjay, Gorin, Yves, Kasinath, Balakuntalam S., Abboud, Hanna E., Ghosh Choudhury, Goutam
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042091/
https://ncbi.nlm.nih.gov/pubmed/24740537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00387.2013
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