Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons. Dysregulation of mammalian target of rapamycin (mTOR) has been implicated in the pathogenesis of PD. However, the underlying mechanism is incompletely elucidated. Here, we show that PD mimetics (6...

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Detalhes bibliográficos
Main Authors: Xu, Yijiao, Liu, Chunxiao, Chen, Sujuan, Ye, Yangjing, Guo, Min, Ren, Qian, Liu, Lei, Zhang, Hai, Xu, Chong, Zhou, Qian, Huang, Shile, Chen, Long
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039615/
https://ncbi.nlm.nih.gov/pubmed/24726895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2014.04.009
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