Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

Rotenone, a common pesticide and inhibitor of mitochondrial complex I, induces loss of dopaminergic neurons and consequential aspects of Parkinson’s disease (PD). However, the exact mechanism of rotenone neurotoxicity is not fully elucidated. Here, we show that rotenone induced reactive oxygen speci...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Toxicol Sci
Egile Nagusiak: Zhou, Qian, Liu, Chunxiao, Liu, Wen, Zhang, Hai, Zhang, Ruijie, Liu, Jia, Zhang, Jinfei, Xu, Chong, Liu, Lei, Huang, Shile, Chen, Long
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2015
Gaiak:
Mechanisms of Rotenone-Induced Apoptosis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274383/
https://ncbi.nlm.nih.gov/pubmed/25304210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu211
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