Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

Rotenone, a common pesticide and inhibitor of mitochondrial complex I, induces loss of dopaminergic neurons and consequential aspects of Parkinson’s disease (PD). However, the exact mechanism of rotenone neurotoxicity is not fully elucidated. Here, we show that rotenone induced reactive oxygen speci...

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Detaylı Bibliyografya
Yayımlandı:Toxicol Sci
Asıl Yazarlar: Zhou, Qian, Liu, Chunxiao, Liu, Wen, Zhang, Hai, Zhang, Ruijie, Liu, Jia, Zhang, Jinfei, Xu, Chong, Liu, Lei, Huang, Shile, Chen, Long
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2015
Konular:
Mechanisms of Rotenone-Induced Apoptosis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274383/
https://ncbi.nlm.nih.gov/pubmed/25304210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu211
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