Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

Rotenone, a common pesticide and inhibitor of mitochondrial complex I, induces loss of dopaminergic neurons and consequential aspects of Parkinson’s disease (PD). However, the exact mechanism of rotenone neurotoxicity is not fully elucidated. Here, we show that rotenone induced reactive oxygen speci...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Toxicol Sci
Main Authors: Zhou, Qian, Liu, Chunxiao, Liu, Wen, Zhang, Hai, Zhang, Ruijie, Liu, Jia, Zhang, Jinfei, Xu, Chong, Liu, Lei, Huang, Shile, Chen, Long
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Mechanisms of Rotenone-Induced Apoptosis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274383/
https://ncbi.nlm.nih.gov/pubmed/25304210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu211
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker