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Sensitivity of Global Translation to mTOR Inhibition in REN Cells Depends on the Equilibrium between eIF4E and 4E-BP1

Initiation is the rate-limiting phase of protein synthesis, controlled by signaling pathways regulating the phosphorylation of translation factors. Initiation has three steps, 43S, 48S and 80S formation. 43S formation is repressed by eIF2α phosphorylation. The subsequent steps, 48S and 80S formation...

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Detalhes bibliográficos
Main Authors: Grosso, Stefano, Pesce, Elisa, Brina, Daniela, Beugnet, Anne, Loreni, Fabrizio, Biffo, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245250/
https://ncbi.nlm.nih.gov/pubmed/22216185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029136
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