Sensitivity of Global Translation to mTOR Inhibition in REN Cells Depends on the Equilibrium between eIF4E and 4E-BP1

Initiation is the rate-limiting phase of protein synthesis, controlled by signaling pathways regulating the phosphorylation of translation factors. Initiation has three steps, 43S, 48S and 80S formation. 43S formation is repressed by eIF2α phosphorylation. The subsequent steps, 48S and 80S formation...

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Detaylı Bibliyografya
Asıl Yazarlar: Grosso, Stefano, Pesce, Elisa, Brina, Daniela, Beugnet, Anne, Loreni, Fabrizio, Biffo, Stefano
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245250/
https://ncbi.nlm.nih.gov/pubmed/22216185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029136
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