Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo

eIF6 is an antiassociation factor that regulates the availability of active 80S. Its activation is driven by the RACK1/PKCβ axis, in a mTORc1 independent manner. We previously described that eIF6 haploinsufficiency causes a striking survival in the Eμ-Myc mouse lymphoma model, with lifespans extende...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Miluzio, Annarita, Oliveto, Stefania, Pesce, Elisa, Mutti, Luciano, Murer, Bruno, Grosso, Stefano, Ricciardi, Sara, Brina, Daniela, Biffo, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741942/
https://ncbi.nlm.nih.gov/pubmed/26462016
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