eIF4E3 forms an active eIF4F complex during stresses (eIF4F(S)) targeting mTOR and re-programs the translatome

The eIF4E are a family of initiation factors that bind the mRNA 5′ cap, regulating the proteome and the cellular phenotype. eIF4E1 mediates global translation and its activity is controlled via the PI3K/AKT/mTOR pathway. mTOR down-regulation results in eIF4E1 sequestration into an inactive complex w...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Weiss, Benjamin, Allen, George Edward, Kloehn, Joachim, Abid, Karim, Jaquier-Gubler, Pascale, Curran, Joseph Alphonsus
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8136781/
https://ncbi.nlm.nih.gov/pubmed/33893802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab267
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