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eIF4E3 forms an active eIF4F complex during stresses (eIF4F(S)) targeting mTOR and re-programs the translatome
The eIF4E are a family of initiation factors that bind the mRNA 5′ cap, regulating the proteome and the cellular phenotype. eIF4E1 mediates global translation and its activity is controlled via the PI3K/AKT/mTOR pathway. mTOR down-regulation results in eIF4E1 sequestration into an inactive complex w...
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| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8136781/ https://ncbi.nlm.nih.gov/pubmed/33893802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab267 |
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