Crosstalk between Ca(2+) signaling and mitochondrial H(2)O(2) is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis

Rotenone, a neurotoxic pesticide, induces loss of dopaminergic neurons related to Parkinson's disease. Previous studies have shown that rotenone induces neuronal apoptosis partly by triggering hydrogen peroxide (H(2)O(2))-dependent suppression of mTOR pathway. However, the underlying mechanism...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Chunxiao, Ye, Yangjing, Zhou, Qian, Zhang, Ruijie, Zhang, Hai, Liu, Wen, Xu, Chong, Liu, Lei, Huang, Shile, Chen, Long
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884936/
https://ncbi.nlm.nih.gov/pubmed/26859572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7183
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