N-acetyl-L-cysteine protects against cadmium-induced neuronal apoptosis by inhibiting ROS-dependent activation of Akt/mTOR pathway in mouse brain

AIMS: This study explores the neuroprotective effects and mechanisms of N-acetyl-L-cysteine (NAC) in mice exposed to cadmium (Cd). METHODS: NAC (150 mg/kg) was intraperitoneally administered to mice exposed to Cd (10-50 mg/L) in drinking water for 6 weeks. The changes of cell damage and death, react...

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Hlavní autoři: Chen, Sujuan, Ren, Qian, Zhang, Jinfei, Ye, Yangjing, Zhang, Zhen, Xu, Yijiao, Guo, Min, Ji, Haiyan, Xu, Chong, Gu, Chenjian, Gao, Wei, Huang, Shile, Chen, Long
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043941/
https://ncbi.nlm.nih.gov/pubmed/24299490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nan.12103
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