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Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival
Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER stress–associated transcription factor XBP-1 in B cells and found that XBP-1 deficiency decelerates malignant progression of C...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4038575/ https://ncbi.nlm.nih.gov/pubmed/24812669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73448 |
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