Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice

Chronic lymphocytic leukemia (CLL) represents 30% of adult leukemia. TCL1 is expressed in ∼ 90% of human CLL. Transgenic expression of TCL1 in murine B cells (Eμ-TCL1) results in mouse CLL. Here we show for the first time that the previously unexplored endoplasmic reticulum (ER) stress response is a...

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Autors principals: Kriss, Crystina L., Pinilla-Ibarz, Javier A., Mailloux, Adam W., Powers, John J., Tang, Chih-Hang Anthony, Kang, Chang Won, Zanesi, Nicola, Epling-Burnette, Pearlie K., Sotomayor, Eduardo M., Croce, Carlo M., Del Valle, Juan R., Hu, Chih-Chi Andrew
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680046/
https://ncbi.nlm.nih.gov/pubmed/22692508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-394346
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