Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival

Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER stress–associated transcription factor XBP-1 in B cells and found that XBP-1 deficiency decelerates malignant progression of C...

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Bibliografiske detaljer
Main Authors: Tang, Chih-Hang Anthony, Ranatunga, Sujeewa, Kriss, Crystina L., Cubitt, Christopher L., Tao, Jianguo, Pinilla-Ibarz, Javier A., Del Valle, Juan R., Hu, Chih-Chi Andrew
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038575/
https://ncbi.nlm.nih.gov/pubmed/24812669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73448
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