Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice

Hematopoietic stem cell transplantation (HCT) is a curative procedure for hematological malignancies, but chronic graft-versus-host disease (cGVHD) remains a major complication after allogeneic HCT. Because donor B cells are essential for cGVHD development and B cells are sensitive to endoplasmic re...

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Опубликовано в: :Blood Adv
Главные авторы: Schutt, Steven D., Wu, Yongxia, Tang, Chih-Hang Anthony, Bastian, David, Nguyen, Hung, Sofi, M. Hanief, Zhang, MengMeng, Liu, Chen, Helke, Kris, Wilson, Carole, Schnapp, Lynn M., Del Valle, Juan R., Hu, Chih-Chi Andrew, Yu, Xue-Zhong
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2018
Предметы:
Immunobiology and Immunotherapy
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5858472/
https://ncbi.nlm.nih.gov/pubmed/29483082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017009068
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