Synthesis of Novel Tricyclic Chromenone-Based Inhibitors of IRE-1 RNase Activity

[Image: see text] Inositol-requiring enzyme 1 (IRE-1) is a kinase/RNase ER stress sensor that is activated in response to excessive accumulation of unfolded proteins, hypoxic conditions, calcium imbalance, and other stress stimuli. Activation of IRE-1 RNase function exerts a cytoprotective effect an...

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Detalhes bibliográficos
Main Authors: Ranatunga, Sujeewa, Tang, Chih-Hang Anthony, Kang, Chang Won, Kriss, Crystina L., Kloppenburg, Bernhard J., Hu, Chih-Chi Andrew, Del Valle, Juan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032190/
https://ncbi.nlm.nih.gov/pubmed/24749861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5002452
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