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Synthesis of Novel Tricyclic Chromenone-Based Inhibitors of IRE-1 RNase Activity
[Image: see text] Inositol-requiring enzyme 1 (IRE-1) is a kinase/RNase ER stress sensor that is activated in response to excessive accumulation of unfolded proteins, hypoxic conditions, calcium imbalance, and other stress stimuli. Activation of IRE-1 RNase function exerts a cytoprotective effect an...
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| 主要な著者: | , , , , , , |
|---|---|
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2014
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4032190/ https://ncbi.nlm.nih.gov/pubmed/24749861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5002452 |
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