Development of tumor-targeting IRE-1 inhibitors for B cell cancer therapy

The IRE-1 kinase/RNase splices the mRNA of the XBP-1 gene, resulting in the spliced XBP-1 (XBP-1s) mRNA that encodes the functional XBP-1s transcription factor that is critically important for the growth and survival of B-cell leukemia, lymphoma and multiple myeloma (MM). Several inhibitors targetin...

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Gepubliceerd in:Mol Cancer Ther
Hoofdauteurs: Shao, Andong, Xu, Qin, Spalek, Walker T., Cain, Christopher F., Kang, Chang Won, Tang, Chih-Hang Anthony, Del Valle, Juan R., Hu, Chih-Chi Andrew
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773214/
https://ncbi.nlm.nih.gov/pubmed/33051362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0127
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