STING regulates BCR signaling in normal and malignant B cells

STING is an endoplasmic reticulum (ER)-resident protein critical for sensing cytoplasmic DNA and promoting the production of type I interferons; however, the role of STING in B cell receptor (BCR) signaling remains unclear. We generated STING V154M knock-in mice and showed that B cells carrying cons...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Mol Immunol
Prif Awduron: Tang, Chih-Hang Anthony, Lee, Avery C., Chang, Shiun, Xu, Qin, Shao, Andong, Lo, Yun, Spalek, Walker T., Pinilla-Ibarz, Javier A., Del Valle, Juan R., Hu, Chih-Chi Andrew
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115116/
https://ncbi.nlm.nih.gov/pubmed/32999453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-00552-0
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