Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization

To relieve endoplasmic reticulum (ER) stress, IRE1 splices XBP1 messenger RNA (mRNA) or engages regulated IRE1-dependent decay (RIDD) of other mRNAs. Upon XBP1 deficiency, IRE1 switches to perform RIDD. We examined IRE1 in XBP1-deficient B cells and discovered that IRE1 undergoes phosphorylation at...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Tang, Chih-Hang Anthony, Chang, Shiun, Paton, Adrienne W., Paton, James C., Gabrilovich, Dmitry I., Ploegh, Hidde L., Del Valle, Juan R., Hu, Chih-Chi Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940306/
https://ncbi.nlm.nih.gov/pubmed/29511123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201709137
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