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Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes
Shiga-toxigenic Escherichia coli (STEC) use subtilase cytotoxin (SubAB) to interfere with adaptive immunity. Its inhibition of immunoglobulin secretion is both rapid and profound. SubAB favors cleavage of the newly synthesized immunoglobulin heavy chain–binding protein (BiP) to yield a C-terminal fr...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768844/ https://ncbi.nlm.nih.gov/pubmed/19808260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090782 |
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