Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes

Shiga-toxigenic Escherichia coli (STEC) use subtilase cytotoxin (SubAB) to interfere with adaptive immunity. Its inhibition of immunoglobulin secretion is both rapid and profound. SubAB favors cleavage of the newly synthesized immunoglobulin heavy chain–binding protein (BiP) to yield a C-terminal fr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hu, Chih-Chi Andrew, Dougan, Stephanie K., Winter, Sebastian Virreira, Paton, Adrienne W., Paton, James C., Ploegh, Hidde L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2009
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768844/
https://ncbi.nlm.nih.gov/pubmed/19808260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090782
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