The Escherichia coli Subtilase Cytotoxin A Subunit Specifically Cleaves Cell-surface GRP78 Protein and Abolishes COOH-terminal-dependent Signaling

GRP78, a molecular chaperone with critical endoplasmic reticulum functions, is aberrantly expressed on the surface of cancer cells, including prostate and melanoma. Here it functions as a pro-proliferative and anti-apoptotic signaling receptor via NH(2)-terminal domain ligation. Auto-antibodies to t...

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Main Authors: Ray, Rupa, de Ridder, Gustaaf G., Eu, Jerry P., Paton, Adrienne W., Paton, James C., Pizzo, Salvatore V.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463347/
https://ncbi.nlm.nih.gov/pubmed/22851173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399808
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