Binding of Tissue-type Plasminogen Activator to the Glucose-regulated Protein 78 (GRP78) Modulates Plasminogen Activation and Promotes Human Neuroblastoma Cell Proliferation in Vitro

The glucose-regulated protein 78 (GRP78) is a plasminogen (Pg) receptor on the cell surface. In this study, we demonstrate that GRP78 also binds the tissue-type plasminogen activator (t-PA), which results in a decrease in K(m) and an increase in the V(max) for both its amidolytic activity and activa...

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Detalhes bibliográficos
Main Authors: Gonzalez-Gronow, Mario, Gomez, Cristian Farias, de Ridder, Gustaaf G., Ray, Rupa, Pizzo, Salvatore V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155680/
https://ncbi.nlm.nih.gov/pubmed/25059665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589341
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