Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes

Shiga-toxigenic Escherichia coli (STEC) use subtilase cytotoxin (SubAB) to interfere with adaptive immunity. Its inhibition of immunoglobulin secretion is both rapid and profound. SubAB favors cleavage of the newly synthesized immunoglobulin heavy chain–binding protein (BiP) to yield a C-terminal fr...

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Main Authors: Hu, Chih-Chi Andrew, Dougan, Stephanie K., Winter, Sebastian Virreira, Paton, Adrienne W., Paton, James C., Ploegh, Hidde L.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768844/
https://ncbi.nlm.nih.gov/pubmed/19808260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090782
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