IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers

Myc activation is a primary oncogenic event in many human cancers; however, these transcription factors are difficult to inhibit pharmacologically, suggesting that Myc-dependent downstream effectors may be more tractable therapeutic targets. Here, we show that Myc overexpression induces endoplasmic...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Xie, Hong, Tang, Chih-Hang Anthony, Song, Jun H., Mancuso, Anthony, Del Valle, Juan R., Cao, Jin, Xiang, Yan, Dang, Chi V., Lan, Roy, Sanchez, Danielle J., Keith, Brian, Hu, Chih-Chi Andrew, Simon, M. Celeste
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873889/
https://ncbi.nlm.nih.gov/pubmed/29381485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95864
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