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IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers
Myc activation is a primary oncogenic event in many human cancers; however, these transcription factors are difficult to inhibit pharmacologically, suggesting that Myc-dependent downstream effectors may be more tractable therapeutic targets. Here, we show that Myc overexpression induces endoplasmic...
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| 出版年: | J Clin Invest |
|---|---|
| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5873889/ https://ncbi.nlm.nih.gov/pubmed/29381485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95864 |
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