M3 Muscarinic Receptor Interaction with Phospholipase C β3 Determines Its Signaling Efficiency

Phospholipase Cβ (PLCβ) enzymes are activated by G protein-coupled receptors through receptor-catalyzed guanine nucleotide exchange on Gαβγ heterotrimers containing G(q) family G proteins. Here we report evidence for a direct interaction between M3 muscarinic receptor (M3R) and PLCβ3. Both expressed...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kan, Wei, Adjobo-Hermans, Merel, Burroughs, Michael, Faibis, Guy, Malik, Sundeep, Tall, Gregory G., Smrcka, Alan V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036259/
https://ncbi.nlm.nih.gov/pubmed/24596086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.538546
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