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M3 Muscarinic Receptor Interaction with Phospholipase C β3 Determines Its Signaling Efficiency
Phospholipase Cβ (PLCβ) enzymes are activated by G protein-coupled receptors through receptor-catalyzed guanine nucleotide exchange on Gαβγ heterotrimers containing G(q) family G proteins. Here we report evidence for a direct interaction between M3 muscarinic receptor (M3R) and PLCβ3. Both expressed...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4036259/ https://ncbi.nlm.nih.gov/pubmed/24596086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.538546 |
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