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Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ
[Image: see text] Etoposide is a topoisomerase II poison that is utilized to treat a broad spectrum of human cancers. Despite its wide clinical use, 2–3% of patients treated with etoposide eventually develop treatment-related acute myeloid leukemias (t-AMLs) characterized by rearrangements of the ML...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American
Chemical
Society
2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4033626/ https://ncbi.nlm.nih.gov/pubmed/24766193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500421q |
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