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Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

We studied patterns of off-target receptor interactions, mostly at G protein-coupled receptors (GPCRs) in the µM range, of nucleoside derivatives that are highly engineered for nM interaction with adenosine receptors (ARs). Because of the considerable interest of using AR ligands for treating diseas...

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Main Authors: Paoletta, Silvia, Tosh, Dilip K., Salvemini, Daniela, Jacobson, Kenneth A.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032265/
https://ncbi.nlm.nih.gov/pubmed/24859150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097858
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