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Use of RNAi Screens to Uncover Resistance Mechanisms in Cancer Cells and Identify Synthetic Lethal Interactions
RNAi loss-of-function screens, which have proven effective to identify genes functionally responsible for cellular phenotypes, can be designed to use different genetic backgrounds or altered environmental conditions to elucidate genetic dependencies. These sorts of screening approaches can be exploi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4031443/ https://ncbi.nlm.nih.gov/pubmed/24847648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2013.12.002 |
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