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Use of RNAi Screens to Uncover Resistance Mechanisms in Cancer Cells and Identify Synthetic Lethal Interactions

RNAi loss-of-function screens, which have proven effective to identify genes functionally responsible for cellular phenotypes, can be designed to use different genetic backgrounds or altered environmental conditions to elucidate genetic dependencies. These sorts of screening approaches can be exploi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Diehl, Paul, Tedesco, Donato, Chenchik, Alex
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031443/
https://ncbi.nlm.nih.gov/pubmed/24847648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2013.12.002
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