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Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer

BACKGROUND: Pancreatic cancer retains a poor prognosis among the gastrointestinal cancers. It affects 230,000 individuals worldwide, has a very high mortality rate, and remains one of the most challenging malignancies to treat successfully. Treatment with gemcitabine, the most widely used chemothera...

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Detalhes bibliográficos
Main Authors: Azorsa, David O, Gonzales, Irma M, Basu, Gargi D, Choudhary, Ashish, Arora, Shilpi, Bisanz, Kristen M, Kiefer, Jeffrey A, Henderson, Meredith C, Trent, Jeffrey M, Von Hoff, Daniel D, Mousses, Spyro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702280/
https://ncbi.nlm.nih.gov/pubmed/19519883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-7-43
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