Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer

BACKGROUND: Pancreatic cancer retains a poor prognosis among the gastrointestinal cancers. It affects 230,000 individuals worldwide, has a very high mortality rate, and remains one of the most challenging malignancies to treat successfully. Treatment with gemcitabine, the most widely used chemothera...

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Hauptverfasser: Azorsa, David O, Gonzales, Irma M, Basu, Gargi D, Choudhary, Ashish, Arora, Shilpi, Bisanz, Kristen M, Kiefer, Jeffrey A, Henderson, Meredith C, Trent, Jeffrey M, Von Hoff, Daniel D, Mousses, Spyro
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702280/
https://ncbi.nlm.nih.gov/pubmed/19519883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-7-43
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