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RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition
PURPOSE: To identify genes whose depletion is detrimental to Pim1-overexpressing prostate cancer cells and to validate this finding in vitro and in vivo. EXPERIMENTAL DESIGN: RNAi screening was employed to identify genes whose depletion is detrimental to Pim1-overexpressing cells. Our finding was va...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086184/ https://ncbi.nlm.nih.gov/pubmed/24771642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3116 |
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