RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition

PURPOSE: To identify genes whose depletion is detrimental to Pim1-overexpressing prostate cancer cells and to validate this finding in vitro and in vivo. EXPERIMENTAL DESIGN: RNAi screening was employed to identify genes whose depletion is detrimental to Pim1-overexpressing cells. Our finding was va...

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Bibliographic Details
Main Authors: van der Meer, Riet, Song, Ha Yong, Park, Seong-Hoon, Abdulkadir, Sarki A., Roh, Meejeon
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086184/
https://ncbi.nlm.nih.gov/pubmed/24771642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3116
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