Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside

[Image: see text] The discovery of a new series of γ-secretase modulators is disclosed. Starting from a triterpene glycoside γ-secretase modulator that gave a very low brain-to-plasma ratio, initial SAR and optimization involved replacement of a pendant sugar with a series of morpholines. This modif...

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Autori principali: Fuller, Nathan O., Hubbs, Jed L., Austin, Wesley F., Creaser, Steffen P., McKee, Timothy D., Loureiro, Robyn M. B., Tate, Barbara, Xia, Weiming, Ives, Jeffrey L., Findeis, Mark A., Bronk, Brian S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2012
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025870/
https://ncbi.nlm.nih.gov/pubmed/24900406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300256p
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