A Pentacyclic Triterpene from Ligustrum lucidum Targets γ-Secretase

Amyloid-beta peptides generated by β-secretase- and γ-secretase-mediated successive cleavage of amyloid precursor protein are believed to play a causative role in Alzheimer’s disease. Thus, reducing amyloid-beta generation by modulating γ-secretase remains a promising approach for Alzheimer’s diseas...

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Veröffentlicht in:ACS Chem Neurosci
Hauptverfasser: Luo, Wenjie, Ip, Fanny C. F., Fu, Guangmiao, Cheung, Kit, Tian, Yuan, Hu, Yueqing, Sinha, Anjana, Cheng, Elaine Y. L., Wu, Xianzhong, Bustos, Victor, Greengard, Paul, Li, Yue-Ming, Sinha, Subhash C., Ip, Nancy Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325170/
https://ncbi.nlm.nih.gov/pubmed/32786303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00389
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