E prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection

Prostaglandins (PGs) are potent lipid mediators that are produced during infections and whose synthesis and signaling networks present potential pharmacologic targets for immunomodulation. PGE(2) acts through the ligation of 4 distinct G protein coupled receptors, E-prostanoid (EP) 1–4. Previous in...

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Hauptverfasser: Aronoff, David M., Lewis, Casey, Serezani, Carlos H., Eaton, Kathryn A., Goel, Deepti, Phipps, John J., Peters-Golden, Marc, Mancuso, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016992/
https://ncbi.nlm.nih.gov/pubmed/19635910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900129
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