Ablation of Leptin Receptor Mediated Extracellular Regulated Kinase Activation Impairs Host Defense against Gram-Negative Pneumonia

The adipocyte-derived hormone, leptin, plays an important role in regulating energy homeostasis and the innate immune response against bacterial infections. Leptin’s actions are mediated by signaling events initiated by phosphorylation of tyrosine residues on the long form of the leptin receptor. We...

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Bibliographische Detailangaben
Hauptverfasser: Mancuso, Peter, Myers, Martin G., Goel, Deepti, Serezani, Carlos. H., O’Brien, Edmund, Goldberg, Jared, Aronoff, David. M., Peters-Golden, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392451/
https://ncbi.nlm.nih.gov/pubmed/22685316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200465
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