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Intrapulmonary Administration of Leukotriene B(4) Enhances Pulmonary Host Defense against Pneumococcal Pneumonia

Leukotriene B(4) (LTB(4)) is a potent lipid mediator of inflammation formed by the 5-lipoxygenase (5-LO)-catalyzed oxidation of arachidonic acid. We have previously shown that (i) LTB(4) is generated during infection, (ii) its biosynthesis is essential for optimal antimicrobial host defense, (iii) L...

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書誌詳細
主要な著者: Mancuso, Peter, Lewis, Casey, Serezani, Carlos Henrique, Goel, Deepti, Peters-Golden, Marc
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863513/
https://ncbi.nlm.nih.gov/pubmed/20231413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01323-09
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