Trop-2-targeting tetrakis-ranpirnase has potent antitumor activity against triple-negative breast cancer

BACKGROUND: Ranpirnase (Rap) is an amphibian ribonuclease with reported antitumor activity, minimal toxicity, and negligible immunogenicity in clinical studies, but the unfavorable pharmacokinetics and suboptimal efficacy hampered its further clinical development. To improve the potential of Rap-bas...

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Bibliografiske detaljer
Main Authors: Liu, Donglin, Cardillo, Thomas M, Wang, Yang, Rossi, Edmund A, Goldenberg, David M, Chang, Chien-Hsing
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015355/
https://ncbi.nlm.nih.gov/pubmed/24606732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-53
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