Trop-2-targeting tetrakis-ranpirnase has potent antitumor activity against triple-negative breast cancer

BACKGROUND: Ranpirnase (Rap) is an amphibian ribonuclease with reported antitumor activity, minimal toxicity, and negligible immunogenicity in clinical studies, but the unfavorable pharmacokinetics and suboptimal efficacy hampered its further clinical development. To improve the potential of Rap-bas...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Liu, Donglin, Cardillo, Thomas M, Wang, Yang, Rossi, Edmund A, Goldenberg, David M, Chang, Chien-Hsing
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2014
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015355/
https://ncbi.nlm.nih.gov/pubmed/24606732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-53
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